Rhophylac: Dosing, Side Effect & Interaction

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Human anti-D Ig

Indications/Uses

Prevention of Rh(D) immunisation in Rh(D) -ve women (ante- & postpartum prophylaxis). Rh(D) -ve patients after incompatible transfusion of Rh(D) +ve blood or other RBC-containing products eg, platelet concentrate.

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Dosage/Direction for Use

Prevention of Rh(D) immunisation in Rh(D) -ve women Antepartum prophylaxis 300 mcg single IV/IM inj. Planned antepartum prophylaxis 300 mcg single dose at 28-30 wk of gestation. Antenatal prophylaxis following complications of pregnancy 300 mcg IV/IM inj administered as soon as possible w/in 72 hr after the at-risk event, repeat every 6-12 wk until delivery time. Postpartum prophylaxis 300 mcg IV/IM administered as soon as possible w/in 72 hr of delivery. Incompatible transfusions of Rh(D) +ve RBCs in Rh(D) -ve patient 10 mcg/mL transfused Rh(D) +ve blood or per 0.5 mL of Rh(D) +ve erythrocyte conc. Max dose: 3,000 mcg.

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Overdosage

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Contraindications

Hypersensitivity to human Ig. Severe thrombocytopenia or other haemostasis disorders.

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Special Precautions

Discontinue use if allergic or anaphylactic type reaction occurs. Not intended for use in Rh(D) +ve individuals or individuals already immunised to Rh(D) antigen. Risk of haemolytic reaction. Patients w/ BMI ≥30. Possibility of transmitting infective agents. Paed patients. Not to be given to newborn infant.

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Use In Pregnancy & Lactation

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Adverse Reactions

Local pain & tenderness at inj site (IM route). Uncommonly, headache; skin reaction, erythema, pruritus; pyrexia, malaise, chills.

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Drug Interactions

Impaired efficacy of live attenuated virus vaccines eg, measles, mumps, rubella or varicella. Misleading +ve results in serological testing.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Rhophylac detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Vaccines, Antisera & Immunologicals

ATC Classification

J06BB01 - anti-D (rh) immunoglobulin ; Belongs to the class of specific immunoglobulins. Used in passive immunizations.

Regulatory Classification

Presentation/Packing

Form

Rhophylac soln for inj 300 mcg/2 mL

Packing/Price

2 mL x 1's

Rhophylac

anti-d immunoglobulins

Manufacturer:

CSL Behring

Distributor:

DKSH