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The effects of anticoagulants may be enhanced by aescin.
The concomitant administration of antibiotics of the aminoglycoside type (e.g. gentamicin) should be avoided, since it can not totally be ruled out that the nephrotoxicity may be enhanced.
The binding of aescin to plasma proteins may be affected by antibiotics. Cephalotin and ampicillin, e.g., cause a rise in the concentration of free serum aescin.
The substances mentioned previously should therefore not be administered concomitantly to Reparil enteric coated tablets.
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