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Pregnancy: Premarin Vaginal Cream should not be used during pregnancy (see Contraindications).
If pregnancy occurs during medication with Premarin Vaginal Cream, treatment should be withdrawn immediately.
Lactation: Premarin Vaginal Cream should not be used during lactation.
Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of breast milk. Detectable amounts of estrogens have been identified in the milk of mothers receiving the drug. Caution should be exercised when estrogens are administered to a nursing woman.
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