There are no data from the use of PIASCLEDINE in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive or fertility toxicity. As a precautionary measure, it is preferable to avoid the use of PIASCLEDINE during pregnancy. There is no information about the excretion of PIASCLEDINE/metabolites in human milk. As a precautionary measure, it is preferable to avoid the use of PIASCLEDINE during breastfeeding.