Nimbex Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cisatracurium besilate

Indications/Uses

Adjunct to general anaesth or sedation in ICU to relax skeletal muscles & facilitate tracheal intubation & mechanical ventilation.

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Dosage/Direction for Use

IV bolus inj Tracheal intubation Adult 0.15 mg/kg over 5-10 sec. Maintenance: 0.03 mg/kg. 2 mg/mL Childn 2-12 yr 0.1 mg/kg over 5-10 sec. Maintenance: 0.02 mg/kg. 5 mg/mL Childn 1 mth-12 yr 0.15 mg/kg over 5-10 sec. Maintenance: 0.02 mg/kg. IV infusion Adult & childn 2-12 yr Initial infusion rate: 3 mcg/kg/min. Maintenance: 1-2 mcg/kg/min. ICU patient Initial infusion rate: 3 mcg/kg/min (range: 0.5-10.2 mcg/kg/min).

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Overdosage

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Contraindications

Hypersensitivity to cisatracurium, atracurium or benzenesulfonic acid.

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Special Precautions

Hypersensitivity to other neuromuscular blockers. Myasthenia gravis & other forms of neuromuscular disease; severe acid-base &/or serum electrolyte abnormalities; malignant hyperthermia-susceptible & burn patients; conditions predisposing to seizures eg, cranial trauma, hypoxic encephalopathy, cerebral oedema, viral encephalitis, uremia. High doses. Not to be administered into blood transfusion infusion line; alkaline soln eg, Na thiopentone. May affect ability to drive & use machines. Renal & hepatic impairment. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Bradycardia; hypotension.

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Drug Interactions

Increased effect w/ enflurane, isoflurane, halothane, ketamine, other non-depolarising neuromuscular blockers, aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin, clindamycin, antiarrhythmics, diuretics, Mg & lithium salts, ganglion-blocking drugs. Increased sensitivity w/ β-blockers, antirheumatic drugs, trimetaphan, chlorpromazine, steroids, phenytoin. Prolonged effect w/ suxamethonium. Decreased effect by phenytoin or carbamazepine. Shortened duration & diminished magnitude w/ anticholinesterases. Incompatibility w/ lactated ringer's inj, ketorolac trometamol, propofol inj emulsion. Not to be mixed in same syringe w/ alkaline soln eg, Na thiopentone.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Nimbex detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Neuromuscular Blocking Agents

ATC Classification

M03AC11 - cisatracurium ; Belongs to the class of other quaternary ammonium-containing agents used as peripherally-acting muscle relaxants.

Regulatory Classification

Presentation/Packing

Form

Nimbex soln for inj 2 mg/mL

Packing/Price

5 mL x 5 × 1's

Form

Nimbex soln for inj 5 mg/mL

Packing/Price

30 mL x 1's

Nimbex

cisatracurium

Manufacturer:

Aspen

Distributor:

Zuellig Pharma