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Symptoms and Signs: The acute dose-limiting toxicity of busulfan in man is myelosuppression.
The main effect of chronic overdosage is bone marrow depression and pancytopenia.
Treatment: There is no known antidote. Dialysis should be considered in the management of overdose as there is one report of successful dialysis of busulfan.
Appropriate supportive treatment should be given during the period of haematological toxicity.
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