Itopride: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Disorders associated with reduced gastrointestinal motility, Non-ulcer dyspepsia

Adult: For the management of gastrointestinal symptoms such as early satiety, postprandial fullness, feeling of bloating, upper abdominal pain or discomfort, nausea and vomiting, anorexia, and heartburn: 50 mg tid; may be reduced if necessary. Treatment recommendations may vary among countries and between individual products (refer to specific product guidelines).

What are the brands available for Itopride in Malaysia?

Ganaton

Administration

Itopride Should be taken on an empty stomach.
Itopride hydrochloride Should be taken on an empty stomach.

Contraindications

Conditions where increased gastrointestinal motility may be harmful (e.g. gastrointestinal haemorrhage, mechanical obstruction or perforation).

Special Precautions

Elderly. Pregnancy and lactation.

Adverse Reactions

Endocrine disorders: Hyperprolactinaemia.
Gastrointestinal disorders: Abdominal pain, diarrhoea, constipation, salivary hypersecretion.
General disorders and administration site conditions: Fatigue, chest pain.
Investigations: Increased serum ALT, decreased WBC count.
Musculoskeletal and connective tissue disorders: Back pain.
Nervous system disorders: Headache, dizziness.
Skin and subcutaneous tissue disorders: Rash.

Drug Interactions

Anticholinergic agents may decrease the therapeutic effect of itopride.

Action

Description:
Mechanism of Action: Itopride is a gastroprokinetic agent. It antagonises dopamine (D₂ subtype) receptors and inhibits acetylcholinesterase, thereby increasing acetylcholine levels and promoting gastrointestinal motility. Additionally, it has antiemetic action by interacting with D₂ receptors in the chemoreceptor trigger zone.
Pharmacokinetics:
Absorption: Rapidly and almost completely absorbed from the gastrointestinal tract. Bioavailability: Approx 60%. Time to peak plasma concentration: 0.5-0.75 hours.
Distribution: Plasma protein binding: Approx 96%, mainly to albumin.
Metabolism: Extensively metabolised in the liver by flavin monooxygenase enzymes.
Excretion: Mainly via urine. Elimination half-life: Approx 6 hours.

Chemical Structure

Storage

Store below 30°C.

MIMS Class

GIT Regulators, Antiflatulents & Anti-Inflammatories

ATC Classification

A03FA07 - itopride ; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.

References

Brayfield A, Cadart C (eds). Itopride Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/03/2025.

Ganaton 50 mg Film-coated Tablet (Siam Bheasach Co., Ltd). MIMS Thailand. http://www.mims.com/thailand. Accessed 03/03/2025.

Ganaton 50 mg Tablet (Abbott Laboratories [M] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 03/03/2025.

Itopride. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 03/03/2025.

Progit 50 mg Film-coated Tablets (PRO.MED.CS Praha a.s.). MHRA. https://products.mhra.gov.uk. Accessed 03/03/2025.

Disclaimer: This information is independently developed by MIMS based on Itopride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com