Infanrix Hexa Drug Interactions

Infanrix hexa can be given concomitantly with pneumococcal conjugate, meningococcal (Men) C conjugate, MenACWY conjugate, MenB, rotavirus, measles, mumps, rubella and varicella vaccines. Data have shown no clinically relevant interference in the antibody response to each of the individual antigens.
When Infanrix hexa was co-administered with MenB and pneumococcal conjugate vaccines, inconsistent results were seen across studies for responses to inactivated poliovirus type 2, pneumococcal conjugate serotype 6B antigen and to the pertussis pertactin antigen but these data do not suggest clinically significant interference.
Data from clinical studies indicate that, when Infanrix hexa is co-administered with pneumococcal conjugate vaccine, the rate of febrile reactions is higher compared to that occurring following the administration of Infanrix hexa alone (see Precautions for guidance on pneumococcal conjugate vaccines).
Due to an increased risk of fever, pain at the injection site, appetite lost and irritability when Infanrix hexa was co-administered with MenB vaccine and 7-valent pneumococcal conjugate vaccine, separate vaccinations can be considered when possible.
As with other vaccines it may be expected that in patients receiving immunosuppressive therapy, an adequate response may not be achieved.