Hemabate

Abortion between 13th & 20th wk of gestation & in the following conditions related to 2nd trimester abortion: Failure of fetus expulsion by another method, premature membrane rupture in intrauterine methods w/ drug loss & insufficient or absent uterine activity, requirement of repeat intrauterine drug instillation for fetus expulsion, inadvertent or spontaneous membrane rupture in the presence of previable fetus & absence of adequate activity for expulsion. Postpartum hemorrhage due to uterine atony which has not responded to conventional methods of management.

Abortion Initially 250 mcg by deep IM inj then subsequently at 1½-3½ hr intervals depending on uterine response. Total dose: Not to exceed 12 mg; max duration: 2 days. Refractory postpartum uterine bleeding Initially 250 mcg by deep IM inj. Total dose: Not to exceed 2 mg (8 doses).

Hypersensitivity. Acute pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease.

Not to be used if fetus in utero has reached viability stage. Not to be considered as feticidal agent. History of asthma, hypotension or HTN, CV disease, anemia, jaundice, diabetes, epilepsy. Patients w/ scarred uteri; spontaneous/incomplete abortion; postpartum hemorrhage; chorioamnionitis. Not recommended in concomitant use w/ oxytocic agents. Renal or hepatic disease. Pregnancy & lactation. Ped patients. Fatal gasping syndrome in premature infants due to benzyl alcohol.

Vomiting, diarrhea, nausea, flushing, chills, cough, headache, endometritis, hiccough, dysmenorrhea-like pain, paresthesia, backache; muscular, eye, inj site, epigastric & chest pain; breast tenderness, drowsiness, dystonia, asthma, tinnitus, vertigo, vasovagal syndrome, mouth dryness, hyperventilation, resp distress, hematemesis, taste alterations, UTI, septic shock, torticollis, lethargy, HTN, tachycardia, pulmonary edema, endometritis from IUCD, nervousness, nosebleed, sleep disorders, dyspnea, chest tightness, wheezing, posterior cervical perforation, weakness, diaphoresis, dizziness, blurred vision, excessive thirst, twitching eyelids, gagging, retching, dry & fullness of throat, choking sensation, thyroid storm, syncope, palpitations, rash, upper resp infection, leg cramps, anxiety, retained placental fragment, shortness of breath; uterine perforation, sacculation & rupture; faintness, lightheadedness.

Augmented activity of other oxytocic agents.

Drugs Acting on the Uterus

G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.

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