Endometrin Dosage/Direction for Use

Posology: Adults: The dose of ENDOMETRIN is 100 mg administered vaginally three times daily starting at oocyte retrieval and continuing for up to 10 weeks total duration (or 12 weeks of gestation).
ENDOMETRIN administered into the vagina twice daily (BD) and three times daily (TDS) dosing have both been shown to be efficacious. However, specific populations may derive greater benefits from BD or TDS dosing regimen and the clinician can tailor treatment to the patient. For women <35 years of age and those patients with adequate ovarian reserve, ENDOMETRIN BD would be the appropriate dose. For patients aged 35 and older and those with diminished ovarian reserve, TDS dosing would be the preferred regimen. Serum progesterone levels may be measured 7 days post fertilisation and used to guide therapy.
Paediatric population: There is no relevant use of ENDOMETRIN in the paediatric population.
Elderly: No clinical data have been collected in patients over age 65.
Use in special populations: There is no experience with use of ENDOMETRIN in patients with impaired liver or renal function.
Method of Administration: ENDOMETRIN is to be placed directly into the vagina by the applicator provided.