Ecosolve Plus Mechanism of Action

Pharmacology: Ecosolve Plus Cream is a combination of broad-spectrum antimycotic, Econazole Nitrate and topical corticosteroid, Triamcinolone Acetonide with anti-inflammatory, antipruritic and antiallergic effects.
Econazole Nitrate is an imidazole antifungal agent which acts against dermatophytes (Trichophyton, Epidermophyton, Microsporum, Pityrosporum); pathogenic yeast (Candida albicans and other Candida species) and molds. The compound acts by damaging the membranes of bacterial and fungal cells; both the cellular and sub-cellular membranes are affected. Econazole apparently disturbs the permeability characteristic of the membrane which allows leakage of potassium and sodium ions and other intra-cellular components. 1t is also active against Gram-positive bacteria, eg. Staphylococci, Streptococci, Bacillus anthracis and Bacteroides fragilis.
Triamcinolone Acetonide is a high potency glucocorticoid used as an anti-inflammatory or immunosuppressive agent. It has a high lipid-water distribution coefficient which favours penetration into the skin and is thus suitable for topical use. It is employed for the treatment of various sensitive inflammatory and allergic dermatoses.
Econazole is applied topically to the skin. It is not for ophthalmic use. Following topical application, systemic absorption is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations found in the stratum corneum greatly exceed the MIC for dermatophytes. Inhibitory concentrations are achieved in the epidermis and as deep as the middle region of the dermis. The use of an occlusive dressing appears to only slightly increase the extent of dermal penetration of the drug. Less than 1% of an applied dose is recovered in urine and feces.
Bioavailability of Triamcinolone following topical application is dependent on the condition of the skin at the application site. Absorption of topical preparations is increased in areas of skin damage, inflammation, or occlusion, or where the stratum corneum is thin such as the eyelids, genitalia and face. Topical preparations of Triamcinolone are metabolized in the skin, and systemic Triamcinolone is metabolized by the liver to inactive metabolites. These inactive metabolites, as well as a small portion of unchanged drug, are excreted in the urine.