Systemic Adverse Reactions: These were very uncommon and never of a serious nature. They consisted mainly of nausea, vomiting, retching, gastrointestinal disorders (0.4%), dizziness (0.1%), headache and drowsiness (0.1%). Hypersensitivity reactions occur very rarely but may be associated with pruritus, rash, urticaria, photodermatitis and occasionally laryngospasm or bronchospasm. The most common side effects associated with chlorhexidine gluconate oral rinses are an increase in staining of teeth and other oral surfaces, and increase in calculus formation and an alteration in taste perception. Chlorhexidine tooth staining is harmless and can be minimised by thorough brushing of teeth before administration. No serious systemic adverse reactions associated with its use have been observed in clinical testing.
Immune System Disorders: Frequency not known: Hypersensitivity including anaphylactic shock.
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