Depot-Medroxyprogesterone acetate (DMPA) injectable suspension is indicated for: Contraception: Contraception (ovulation suppression).
Gynecology: Treatment of endometriosis.
Treatment of menopausal vasomotor symptoms.
Oncology: Adjunctive and/or palliative treatment of recurrent and/or metastatic endometrial or renal carcinoma.
Treatment of hormonally-dependent, recurrent breast cancer in post-menopausal women.
Long-term Use: Since loss of bone mineral density (BMD) may occur in pre-menopausal women who use DMPA injection long-term (see Additional Warnings and Precautions for Specific Use or Formulation: Contraception/Endometriosis - Injectable Formulations: Loss of Bone Mineral Density under Precautions and Pharmacology: Pharmacodynamics: Clinical Studies: Bone Mineral Density Studies under Actions), a risk/benefit assessment, which also takes into consideration the decrease in BMD that occurs during pregnancy and/or lactation, should be considered.