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Fluorouracil is contraindicated in patients: who have any known hypersensitivity to fluorouracil or its excipients; who are debilitated; who are suffering a poor nutritional state; who are suffering from bone marrow depression following radiotherapy or therapy with other antineoplastic agents (leucocyte count less than 5,000/mm3, platelet count less than 100,000/mm3); who are suffering from a potentially serious infection; who are pregnant; with known complete dihydropyrimidine dehydrogenase (DPD) deficiency (see Precautions).
Fluorouracil must not be taken within 4 weeks of treatment with brivudine, sorivudine or their chemically related analogues. Brivudine, sorivudine and their analogues are potent inhibitors of the enzyme dihydropyrimidine dehydrogenase (DPD), which degrades fluorouracil (see Interactions).
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