Dalacin C 150/Sterile Solution Dosage/Direction for Use

Dosage in Adults: Clindamycin phosphate IM administration should be used undiluted.
Clindamycin phosphate IV administration should be diluted (see Special Precautions for Disposal and Other Handling: Dilution for IV use and IV infusion rates under Cautions for Usage).
Clindamycin phosphate (IM or IV administration): The usual daily adult dosage of clindamycin phosphate for infections of the intra-abdominal area, female pelvis, and other complicated or serious infections is 2400-2700 mg given in 2, 3, or 4 equal doses. Less complicated infections due to more susceptible microorganisms may respond to lower doses such as 1200-1800 mg/day administered in 3 or 4 equal doses.
Doses of up to 4800 mg daily have been used successfully.
Single IM doses of greater than 600 mg are not recommended.
Clindamycin hydrochloride capsules (oral administration): 600-1800 mg/day divided in 2, 3 or 4 equal doses. To avoid the possibility of oesophageal irritation, clindamycin HCl capsules should be taken with a full glass of water and no less than 30 minutes before lying down.
Dosage in Children (from 2 years of age): Clindamycin should be dosed based on total body weight regardless of obesity.
Clindamycin phosphate (IM or IV administration): 20-40 mg/kg/day in 3 or 4 equal doses.
Clindamycin hydrochloride capsules (oral administration) for children who are able to swallow capsules: To avoid the possibility of oesophageal irritation, clindamycin HCl capsules should be taken with a full glass of water and no less than 30 minutes before lying down. Clindamycin capsules are not suitable for children who are unable to swallow them whole.
Doses of 8-25 mg/kg/day in 3 or 4 equal doses.
Dosage in Elderly: Pharmacokinetic studies with clindamycin have shown no clinically important differences between young and elderly subjects with normal hepatic function and normal (age-adjusted) renal function after oral or intravenous administration. Therefore, dosage adjustments are not necessary in the elderly with normal hepatic function and normal (age-adjusted) renal function (see Pharmacology: Pharmacokinetics under Actions).
Dosage in Renal Impairment: Clindamycin dosage modification is not necessary in patients with renal insufficiency.
Dosage in Hepatic Impairment: Clindamycin dosage modification is not necessary in patients with hepatic insufficiency.
Dosage in Specific Indications: (a) Treatment of Beta-Hemolytic Streptococcal Infections: Refer to the dosage recommendations previously mentioned (see Dosage in Children (from 2 years of age) as previously mentioned). Treatment should be continued for at least 10 days.
(b) Inpatient Treatment of Pelvic Inflammatory Disease: Clindamycin phosphate 900 mg (IV) every 8 hours daily plus an antibiotic with an appropriate gram-negative aerobic spectrum administered IV, e.g., gentamicin 2.0 mg/kg followed by 1.5 mg/kg every 8 hours daily in patients with normal renal function. Continue (IV) drugs for at least 4 days and at least 48 hours after the patient improves. Then continue oral clindamycin hydrochloride 450-600 mg q6h daily to complete 10-14 days total therapy.
(c) Treatment of Chlamydia trachomatis Cervicitis: Clindamycin hydrochloride capsules orally 450 mg 4 times daily for 10-14 days.
(d) Treatment of Toxoplasmic Encephalitis in Patients with AIDS: Clindamycin phosphate IV or clindamycin hydrochloride orally 600-1200 mg every 6 hours for 2 weeks followed by 300-600 mg orally every 6 hours. The usual total duration of therapy is 8 to 10 weeks. The dose of pyrimethamine is 25 to 75 mg orally each day for 8 to 10 weeks. Folinic acid 10 to 20 mg/day should be given with higher doses of pyrimethamine.
(e) Treatment of Pneumocystis jiroveci (previously classified as Pneumocystis carinii) Pneumonia in Patients with AIDS: Clindamycin phosphate IV 600 to 900 mg every 6 hours or 900 mg IV every 8 hours or clindamycin hydrochloride 300 to 450 mg orally every 6 hours for 21 days; and Primaquine 15 to 30 mg dose orally once daily for 21 days.
(f) Treatment of Acute Streptococcal Tonsillitis/Pharyngitis: Clindamycin hydrochloride capsules 300 mg orally twice daily for 10 days.