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Concomitant administration of Vancomycin and anesthetic agents has been associated with erythema and histamine-like flushing, and anaphylactic reactions.
Because of the possibility of additive toxicities, the concurrent, sequential systemic or topical use of other ototoxic and/or nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, bacitracin, cisplatin, colistin, polymyxin B) and Vancomycin requires careful serial monitoring of renal and auditory function. These drugs should be used with caution in patients receiving Vancomycin therapy.
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