Cefpar SB Dosage/Direction for Use

Recommended Dosage: Adults: Daily dosage recommendations for sulbactam/cefoperazone in adults are as follows: (See Table 1.)

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Doses should be administered every 12 hrs in equally divided doses.
In severe or refractory infections, the daily dosage of sulbactam/cefoperazone may be increased up to 8 g (ie, 4 g cefoperazone activity). Patients may require additional cefoperazone administered separately. Doses should be administered every 12 hrs in equally divided doses. The recommended maximum daily dosage of sulbactam is 4 g.
Renal Dysfunction: Dosage regimens of sulbactam/cefoperazone should be adjusted in patients with marked decrease in renal function (creatinine clearance of <30 mL/min) to compensate for the reduced clearance of sulbactam. Patients with creatinine clearances between 15 and 30 mL/min should receive a maximum of 1 g of sulbactam administered every 12 hrs (maximum daily dosage of 2 g sulbactam), while patients with creatinine clearances of <15 mL/min should receive a maximum of 500 mg of sulbactam every 12 hrs (maximum daily dosage of 1 g sulbactam). In severe infections, it may be necessary to administer additional cefoperazone.
The pharmacokinetic profile of sulbactam is significantly altered by hemodialysis. The serum half-life of cefoperazone is reduced slightly during hemodialysis. Thus, dosing should be scheduled to follow a dialysis period.
Children: Daily dosage recommendations for sulbactam/cefoperazone in children are as follows: (See Table 2.)

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Doses should be administered every 6 to 12 hours in equally divided doses. In serious or refractory infections, these dosages may be increased up to 160 mg/kg/day. Doses should be administered in 2-4 equally divided doses.
Neonates: For neonates in the 1st week of life, the drug should be given every 12 hrs. The maximum daily dosage of sulbactam in pediatrics should not exceed 80 mg/kg/day. For doses of sulbactam/cefoperazone requiring >80 mg/kg/day cefoperazone activity, additional cefoperazone should be administered separately.
Route of Administration: Intramuscular: Lidocaine HCl 2% is a suitable vehicle for intramuscular administration but not for initial reconstitution (see Incompatibilities under Cautions for Usage and Reconstitutions as follows).
Intravenous: For intermittent infusion, each vial of sulbactam/cefoperazone should be reconstituted with the appropriate amount (see Reconstitutions as follows) followed by administration over 15 to 60 minutes.
Lactated Ringer's Solution is a suitable vehicle for intravenous infusion, however, not for initial reconstitution (see Incompatibilities under Cautions for Usage and Reconstitutions as follows). For intravenous injection, each vial should be reconstituted (see Reconstitutions as follows) and administered over a minimum of 3 minutes.
Reconstitutions: Reconstitute one vial Cefoperazone/Sulbactam containing 1.0 g as follows: (See Table 3.)

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