Adult: In cases due to uterine atony that has not responded to conventional treatment: Initially, 250 mcg via deep IM inj. If necessary, dose may be repeated at intervals of at least 15-90 minutes. Max total dose: 2 mg.
Intramuscular Pregnancy termination in the 2nd trimester
Adult: Initially, 250 mcg via deep IM inj. Subsequent doses of 250 mcg may be given at intervals of 1.5-3.5 hours according to the uterine response. Dose may be increased to 500 mcg if uterine contractility is inadequate. Max total dose: 12 mg. Continuous administration for >2 days is not recommended. If preferred, a test dose of 100 mcg may be given initially.
What are the brands available for Carboprost in Malaysia?
Acute pelvic inflammatory disease; active cardiac and pulmonary disease. Active renal and hepatic disease.
Special Precautions
Patient with compromised (scarred) uteri; history of anaemia, CV disease, hypertension, hypotension, or diabetes mellitus; history of glaucoma or raised intraocular pressure; history of asthma, pulmonary disease, or seizure disorder; history of jaundice and renal or hepatic disease. Not indicated for induction of labour. Consider pretreatment or concurrent use of antiemetics and antidiarrhoeal drugs to reduce gastrointestinal effects.
Adverse Reactions
Significant: Transient fever, gastrointestinal effects, hypertension, transient bronchoconstriction, decreased maternal arterial oxygen content. Cardiac disorders: Tachycardia, palpitations. Ear and labyrinth disorders: Vertigo, tinnitus. Eye disorders: Blurred vision, eye pain. Gastrointestinal disorders: Diarrhoea, nausea, vomiting, dysgeusia, upper abdominal pain, dry mouth. General disorders and administration site conditions: Chills, inj site pain. Musculoskeletal and connective tissue disorders: Back pain, myalgia. Nervous system disorders: Headache, dizziness, paraesthesia, somnolence. Psychiatric disorders: Sleep disorder. Renal and urinary disorders: UTI. Reproductive system and breast disorders: Endometritis, retained placenta or membranes, uterine haemorrhage, pelvic pain, breast tenderness. Respiratory, thoracic and mediastinal disorders: Cough, respiratory distress, asthma, dyspnoea, hyperventilation. Skin and subcutaneous tissue disorders: Hyperhidrosis. Vascular disorders: Flushing, syncope.
Termination of pregnancy: Perform cervical exam following pregnancy termination.
Drug Interactions
May potentiate the effect of oxytocics.
Action
Description: Mechanism of Action: Carboprost is a synthetic analogue of endogenous dinoprost (prostaglandin F2α). It stimulates uterine contractility, resulting in the expulsion of products of conception. When used in postpartum haemorrhage, carboprost produces haemostasis at the placentation site through myometrial contractions thus preventing blood loss. Pharmacokinetics: Absorption: Rapidly absorbed after IM administration. Time to peak plasma concentration: 30 minutes.
Chemical Structure
Carboprost Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5281075, Carboprost. https://pubchem.ncbi.nlm.nih.gov/compound/Carboprost. Accessed Mar. 28, 2025.
G02AD04 - carboprost ; Belongs to the class of prostaglandins. Used to induce abortion or augment labour and to minimize blood loss from the placental site.
References
Anon. Carboprost. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 04/02/2025.Brayfield A, Cadart C (eds). Carboprost. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/02/2025.Capliprost 150 mcg/mL (Unimed Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 18/03/2025.Carboprost. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 04/02/2025.Hemabate Injection Solution (Pharmacia & Upjohn Company LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 04/02/2025.Hemabate Sterile Solution (Pfizer Limited). MHRA. https://products.mhra.gov.uk. Accessed 04/02/2025.Joint Formulary Committee. Carboprost. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/02/2025.Pfizer New Zealand Limited. Prostin 15M 250 microgram/mL Solution for Injection data sheet 15 April 2019. Medsafe. http://www.medsafe.govt.nz. Accessed 04/02/2025.
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