Bendared Caution For Usage

Special precautions for disposal and other handling: When handling Bendamustine, inhalation, skin contact or contact with mucous membranes should be avoided (wear gloves and protective clothes). Contaminated body parts should be carefully rinsed with water and soap, the eyes should be rinsed with physiological saline solution. If possible it is recommended to work on special safety workbenches (laminar flow) with liquid-impermeable, absorbent disposable foil. Pregnant personnel should be excluded from handling cytostatics.
The concentrate for solution for infusion has to be diluted with sodium chloride 9 mg/ml (0.9%) solution for injection and then administered by intravenous infusion. Aseptic technique is to be used.
Incompatibilities: This medicinal product must not be mixed with other medicinal products except those mentioned in section as follows: Dilution: Aseptically withdraw the volume needed for the required dose from the bendamustine 180 mg/4 ml vial. Dilute the total recommended dose of Bendamustine hydrochloride 180 mg/4 ml with 0.9% sodium chloride solution to produce a final volume of about 500 ml.
While diluting the product it should be noted that the concentration (45 mg/ml) of bendamustine in Bendamustine is higher than in usual bendamustine concentrates resulting from reconstitution of bendamustine powder containing medicinal products.
Bendamustine hydrochloride 180 mg/4 ml must be diluted with 0.9% NaCl solution and not with any other injectable solutions.
Administration: The solution is administered by intravenous infusion over 30-60 min.
The vials are for multiple dose use.
Any unused product or waste material should be disposed of in accordance with local requirements.