Axtriol-B Mechanism of Action

Pharmacology: Pharmacodynamics: Calcipotriol is a vitamin D analogue. Calcipotriol induces differentiation and suppresses proliferation of keratinocytes. This is the proposed basis for its effect in psoriasis.
Like other topical corticosteroids, Betamethasone Dipropionate has anti-inflammatory, antipruritic, vasoconstrictive and immunosuppressive properties, however, without curing the underlying condition. Through occlusion the effect can be enhanced due to increased penetration of the stratum corneum. The incidence of adverse events will increase because of this. In general, the mechanism of the anti-inflammatory activity of the topical steroids is unclear.
Pharmacokinetics: Application to psoriasis plaques and under occlusive dressings may increase the absorption of topical corticosteroids. Following systematic exposure, both active ingredients-calcipotriol and betamethasone dipropionate-are rapidly and extensively metabolised. One metabolite of calcipotriol and one metabolite of betamethasone dipropionate were quantifiable in some of the patients.