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Pharmacology: Mechanism of Action: Miconazole is an imidazole antifungal agent with some antibacterial activity. It has some activity against Aspergillus spp., Cryptococcus neoformans, Pseudallescheria boydii, and some Gram-positive bacteria including staphylococci and streptococci.
Pharmacokinetics: Miconazole is absorbed from the gastrointestinal tract. Up to 20% of a dose given by mouth is excreted mainly as metabolites in the urine over 4 days. Up to 55% is excreted unchanged in the faeces over 6 days. There is little absorption through skin or mucous membranes.
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