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Acyclovir cream should not be applied to mucous membranes, eg. in the mouth, eyes or vagina. In severely immune-compromised patients (eg. AIDS patients or bone marrow transplant recipients), oral acyclovir dosing should be considered.
Use in Pregnancy and Lactation: No information is available on the effects of topical administration of acyclovir during human pregnancy. The use of acyclovir cream should be considered when the potential benefits outweight the possibility of known risk.
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