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Live organism vaccines: Vaccinations with live organism vaccines are not recommended in immunocompromised individuals (see Precautions).
Nalidixic Acid: Nalidixic acid together with high-dose intravenous Melphalan has caused deaths in children due to haemorrhagic enterocolitis.
In paediatric population, for the Busulfan-Melphalan regimen it has been reported that the administration of melphalan less than 24 hours after the last oral busulfan administration may influence the development of toxicities (Inj).
Cyclosporin: Impaired renal function has been described in bone marrow transplant/haemopoietic stem cell rescue patients who were conditioned with high-dose intravenous Melphalan and who subsequently received cyclosporin to prevent graft-versus-host disease.
Tab: Busulfan: In paediatric population, for the Busulfan-Melphalan regimen it has been reported that the administration of melphalan less than 24 hours after the last oral busulfan administration may influence the development of toxicities.
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