Airtal Drug Interactions

Lithium and Cardiac Glycosides, like Digoxin: Aceclofenac (Airtal), like many non-steroidal anti-inflammatory drugs, may increase the plasma concentrations of lithium and Digoxin. The combination should be avoided unless frequent monitoring of lithium and digoxin levels can be performed.
Diuretics: Studies on animals show the possibility that Aceclofenac (Airtal), like other non-steroidal anti-inflammatory drugs, could interfere with the natriuretic action of diuretics. Diuretics can increase the risk of nephrotoxicity of NSAIDs. This property could be clinically significant in patients with hypertension or impaired cardiac function. When concomitant administration with potassium sparing diuretics is employed, serum potassium should be monitored.
Antihypertensives: Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the effect of antihypertensives. The risk of acute renal insufficiency, which is usually reversible, may be increased in some patients with compromised renal function (e.g. dehydrated patients or elderly patients) when ACE-inhibitors or angiotensin II receptor antagonists are combined with NSAIDs. Therefore, the combination of Aceclofenac (Airtal) with antihypertensives should be administered with caution, especially in the elderly. Patients should be adequately hydrated and consideration should be given to monitoring of renal function after initiation of concomitant therapy, and periodically thereafter.
Effects of Aceclofenac (Airtal) were not observed on the control of blood pressure when it was administered together with bendroflumethiazide, however it is not possible to rule out interaction with other antihypertensive drugs.
Anticoagulants: Like other non-steroidal anti-inflammatory drugs, Aceclofenac (Airtal), may enhance the action of anticoagulants due to a possible inhibition of platelet aggregation. Patients who received combined treatment with anticoagulants and Aceclofenac (Airtal) must be adequately monitored.
Antiplatelet antiaggregants: Aceclofenac (Airtal), like many non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding when combined with antiplatelet antiaggregants.
Oral antidiabetic: The possibility of altering the dose of hypoglycaemic agents must be taken into account when Aceclofenac (Airtal) is administered.
Methotrexate: Precautions must be taken if non-steroidal anti-inflammatory drugs and Methotrexate are both administered within an interval of less than 24 hours, because non-steroidal anti-inflammatory drugs can increase the plasma concentration of Methotrexate, causing greater toxicity.
Corticosteroids: The risk of gastrointestinal ulceration or bleeding may be increased when Aceclofenac (Airtal) is administered with corticosteroids.
Other anti-inflammatory drugs: Avoid concomitant treatment with Acetylsalicylic Acid and other non-steroidal anti-inflammatory drugs as this may increase the frequency of the side effects, including gastrointestinal bleeding.
Selective serotonin reuptake inhibitors (SSRIs): Aceclofenac (Airtal), like many non-steroidal anti-inflammatory drugs (NSAIDs) could increase the risk of gastrointestinal bleeding when it is combined with SSRIs.
Cyclosporine, tacrolimus: The effect of non-steroidal anti-inflammatory drugs on the renal prostaglandin may increase the nephrotoxicity of Cyclosporine or tacrolimus. During combination therapy it is therefore important to carefully monitor renal function.
Zidovudine: When non-steroidal anti-inflammatory drugs (NSAIDs) like Aceclofenac (Airtal) are given with zidovudine there is an increased risk of haematological toxicity. There are indications of an increased risk of haemoarthroses and haematoma in HIV(+) haemophiliacs receiving concurrent treatment with zidovudine and ibuprofen.
Mifepristone: NSAIDs should not be used for 8-12 days after mifepristone administration as NSAIDs can reduce the effect of mifepristone.
Quinolone antibiotics: Animal data indicate that NSAIDs can increase the risk of convulsions associated with quinolone antibiotics. Patients taking NSAIDs and quinolones may have an increased risk of developing convulsions.