Actos Dosage/Direction for Use

Actos should be taken orally once daily with or without food.
Dosage in Adults: Actos may be initiated at 15 mg or 30 mg once daily. The dose may be increased in increments up to 45 mg once daily.
In combination with metformin, the current metformin dose can be continued upon initiation of pioglitazone therapy.
In combination with sulphonylurea, the current sulphonylurea dose can be continued upon initiation of pioglitazone therapy. If patients report hypoglycaemia, the dose of sulphonylurea should be decreased.
Elderly: No dosage adjustment is necessary for elderly patients.
Patients with renal impairment: No dosage adjustment is necessary in patients with impaired renal function (creatinine clearance >4 mL/min). No information is available from dialysed patients therefore pioglitazone should not be used in such patients.
Patients with hepatic impairment: Pioglitazone should not be used in patients with hepatic impairment.
Children and adolescents: There are no data available on the use of pioglitazone in patients under 18 years of age, and therefore its use is not recommended in this age group.