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Although reproductive toxicology in animals gave no evidence of teratogenic potential, ZOLADEX should not be used in pregnancy as there is a theoretical risk of abortion or foetal abnormality if LHRH agonists are used during pregnancy. Potentially fertile women should be examined carefully before treatment to exclude pregnancy. Non-hormonal methods of contraception should be employed during therapy and in the case of endometriosis until menses are resumed.
Pregnancy should be excluded before ZOLADEX is used for assisted reproduction. The clinical data from use in this setting are limited but the available evidence suggests there is no causal association between ZOLADEX and any subsequent abnormalities of oocyte development or pregnancy and outcome.
The use of ZOLADEX during breast feeding is not recommended.
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