Voxatic Mechanism of Action

Pharmacology: The main mechanism of action of levofloxacin is through inhibition of DNA-gyrase, the type of topoisomerase. This results in inhibition of bacterial DNA replication and transcription processes.
Pharmacokinetics: Concomitant administration with food has little effect on levofloxacin absorption. Levofloxacin is widely distributed to all parts of the body with high concentrations. Levofloxacin is also well penetrated into lung tissue. The concentration in lung tissue is 2 to 5 times greater than the plasma concentration.
Levofloxacin is metabolized in a very small portion, metabolites turns into desmethyl-levofloxacin and levofloxacin N-oxide. The metabolite amounts to <5% of the dose excreted in the urine.
Primary excretion is done through the kidney canal (>85% of given dose). The clearance of levofloxacin is reduced and the plasma elimination half-life is extended in patients with impaired renal function (CrCl ≤80 mL/min), it is necessary to adjust the dose to these patients to avoid drug accumulation. Most of these drugs are not metabolized in the body. Approximately 85% of the doses administered excreted through urine without changes its form.