VoLox Eye Drop Mechanism of Action

Levofloxacin exerts a broad-spectrum potent antibacterial activity against organisms causing ophthalmological infections, including gram-positive bacteria, gram-negative bacteria, and anaerobic bacteria. Levofloxacin, an optical isomer of Ofloxacin (l-form), has two times potent antibiotic activity than Ofloxacin.
Pharmacology: Antibacterial activity: Antibacterial activity: Levofloxacin has in vitro broad-spectrum potent antibacterial activity against microorganisms causing ocular infections, including gram-positive bacteria (Staphylococcus sp., Streptococcus sp. [including S. pneumoniae], Micrococcus sp., Enterococcus sp., Corynebacterium sp., etc.), gram-negative bacteria (Pseudomonas sp. Serratia sp., Klebsiella sp., Proteus sp., Acinetobacter sp., Enterobacter sp., etc.), and anaerobic bacteria (Propionibacterium acnes, etc.).
The antibacterial activity of Levofloxacin against standard strains for each bacteria and clinically isolated bacteria identified in patients with external ocular infections was about twice as potent as that of Ofloxacin (in vitro).
Effects on experimental Pseudomonas aeruginosa keratitis in rabbits: Levofloxacin ophthalmic solution was effective in preventing experimental P. aeruginosa keratitis in rabbits.
Mechanism of action: Main mechanism of action of Levofloxacin is to inhibit DNA gyrase activities of bacteria. Its effect is two times greater than that Ofloxacin. There was no difference between MICs and MBCs, indicating its effect being bactericidal. Also bacteriolysis around the MICs was shown in morphological observation.