Ulcron Mechanism of Action

Pharmacology: ULCRON contains sucralfate, a complex substance from a sucrose sulfate and aluminium hydroxide.
Sucralfate is not significantly absorbed from the gastro-intestinal tract and the from of the absorbed dissaccharide sulfate is excreted through urine.
ULCRON promotes a local action of accelerating the healing of gastric and duodenal ulcers.
The underlying studies indicate that ULCRON (sucralfate) has a working mechanism as follows: 1. Forming a complex with protein exudation at the ulcer site.
2. Forming a layer coating with albumin that blocks the diffusion of the hydrogen ions.
3. Trials in men indicate that medication with ULCRON at the recommended dosage of 2 tablets, 3-4 times a day will result in the inhibition of pepsin activity in the gastric juice up to 32 %.
Observation on the previously mentioned description shows that in the cases of gastric ulcers medication, sucralfate does not function as antacids. Instead, it works to form an ulcer adherent complex that covers the ulcer site. In this way are the ulcers protected against barrier breakers as gastric juice, pepsin and bile salts.