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Pregnancy: There are no data from the use of trimetazidine in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity (see Toxicology: Preclinical safety data under Actions). As a precautionary measure, it is preferable to avoid the use of trimetazidine during pregnancy.
Breastfeeding: It is unknown whether trimetazidine is excreted in human milk. A risk to the newborns/infants cannot be excluded. Trimetazidine should not be used during breast-feeding.
Fertility: Reproductive toxicity studies have shown no effect on fertility in female and male rats (see Toxicology: Preclinical safety data under Actions).
