Triplixam Drug Interactions

Drugs increasing risk of angioedema: Sacubitril/valsartan, racecadotril, mTOR inhibitors (e.g. sirolimus, everolimus, temsirolimus), and gliptins (e.g. linagliptin, saxagliptin, sitagliptin, vildagliptin).
Drugs inducing hyperkalaemia: Aliskiren, potassium salts, potassium-sparing diuretics, ACE inhibitors, angiotensin-II receptors antagonists, NSAIDs, heparins, immunosuppressant agents such as ciclosporin or tacrolimus, trimethoprim and co-trimoxazole (trimethoprim/sulfamethoxazole).
Contraindicated: Aliskiren in diabetic or impaired renal patients, extracorporeal treatments.
Not recommended: Lithium, aliskiren in patients other than diabetic or impaired renal patients, concomitant therapy with ACE inhibitor and angiotensin-receptor blocker, estramustine, potassium-sparing drugs (e.g triamterene, amiloride), potassium salts, dantrolene (infusion), grapefruit or grapefruit juice.
Special care: Baclofen, non-steroidal anti-inflammatory medicinal products (included acetylsalicylic acid at high doses), antidiabetic agents (insulin, hypoglycaemic agents), non-potassium-sparing diuretics and potassium-sparing diuretics (eplerenone, spironolactone), Torsades de pointes inducing drugs, amphotericin B (IV route), glucocorticoids and mineralocorticoids (systemic route), tetracosactide, stimulant laxatives, cardiac glycosides, allopurinol, CYP3A4 inducers, CYP3A4 inhibitors.
To be taken into consideration: Imipramine-like antidepressants (tricyclics), neuroleptics, other antihypertensive agents and vasodilatators, tetracosactide, allopurinol, cytostatic or immunosuppressive agents, systemic corticosteroids or procainamide, anaesthetic drugs, diuretics (thiazide or loop diuretics), sympathomimetics, gold, metformin, iodinated contrast media, calcium (salts), ciclosporin, atorvastatin, digoxin, warfarin, tacrolimus, simvastatin, mTOR inhibitors.