Ripizol Overdosage

Human Experience: Common adverse reactions occurred with oral ARIPIPRAZOLE overdosage (alone or combination with other substances) include vomiting, somnolence, and tremor. Other clinically important signs and symptoms observed in one or more patients with ARIPIPRAZOLE overdoses (alone or with other substances) include acidosis, aggression aspartate aminotransferase increased, atrial fibrillation bradycardia, coma, confusional state, convulsion, blood creatine phosphokinase increased, depressed level of consciousness, hypertension, hypokalemia, hypotension, lethargy, loss of consciousness, QRS complex prolonged, QT prolonged, pneumonia aspiration, respiratory arrest, status epilepticus, and tachycardia.
Management of Overdose: No specific information is available on the treatment of overdose with ARIPIPRAZOLE. An electrocardiogram should be obtained in case of overdose and if QT interval prolongation is present, cardiac monitoring should be instituted. Otherwise, management of overdose should concentrate on supportive therapy maintaining an adequate airway, oxygenation and ventilation, and management of symptoms. Close medical supervision and monitoring should continue until the patient recovers.
Charcoal: In the event of an overdose of ARIPIPRAZOLE an early charcoal administration may be useful in partially preventing the absorption of ARIPIPRAZOLE. Administration of 50 g of activated charcoal, one hour after a single 15 mg oral dose of ARIPIPRAZOLE, decreased the mean AUC and Cmax of ARIPIPRAZOLE.
Hemodialysis: Although there is no information on the effect of hemodialysis in treating an overdose with ARIPIPRAZOLE, hemodialysis is unlikely to be useful in overdose management since ARIPIPRAZOLE is highly bound to plasma proteins.