Resyno One Dosage/Direction for Use

Instruction for Use: Before the Use: The gel of the syringe must be used immediately after its packaging is opened.
The injection site should be disinfected with alcohol or other appropriate disinfection solution that isn't containing quaternary ammonium salts prior to administration.
Use a 23G needle packed in the blister. Do not use if the package of needle is damaged.
To ensure a tight connection and prevent leakage during administration, secure the needle and syringe tightly. If improper connection is made, it may burst and injure the user.
Do not over tighten or apply excessive leverage when attaching the needle or removing the needle case, as this may break the syringe tip.
Carefully push the plunger rod until a small droplet is visible at the tip of the needle before product injection to check if the needle is clogged. If the needle is clogged, do not use the product. If a clogged needle is used, an injury may occur on account of damage of the syringe.
Remove synovial fluid or effusion before injecting the product, if needed.
Directions for Assembly: Hold the luer-lock adapter of the prefilled syringe with one hand, and hold the syringe cap with the other hand.
Remove the syringe cap by turning it counterclockwise.
*Note: Do not grasp the body of the syringe when removing the syringe cap as there is a risk of breakage.
Remove the needle hub cap by turning it counterclockwise.
*Note: Be careful not to touch the needle and syringe inlet to maintain sterility after detachment.
Secure the syringe barrel and luer-lock adapter firmly using thumb and index finger.
Insert the screw thread of the needle firmly into the syringe and connect them while screwing clockwise the needle case which is holding with the other hand.
*Note: Do not grasp the body of the syringe when assembling the needle as there is a risk of breakage.
Connecting the needle while holding the syringe body may cause a spinning with no traction, and leakage may occur when using an incomplete assembly.
Remove the needle case before injection.
Administration: The product is injected into the knee joint and is administrated as a single intra-articular injection.
Recommended Dose: The recommended treatment regimen is 2 mL (single-dose) injection in the knee.
Injection interval (more than 6 months after the last injection is recommended) should be carefully considered according to the patient's symptoms.
After the Use: The used syringe, needle and remaining gel are disposed to according to healthcare waste management procedure (i.e., national or local regulations) after use.