Monitor serum Ca & K levels regularly during therapy. Possible severe K depletion; discontinue use when serum K falls to 5 mmol/L. Monitor serum Ca levels wkly to detect early development of hyper- & hypocalcemia. Hypomagnesemia may occur; monitor serum Mg levels. Discontinue treatment in the event of clinically significant constipation until normal bowel movement resumes. Do not use Mg-containing laxatives. Care should be taken w/ PO to avoid aspiration that may lead to bronchopulmonary complications. Concomitant use w/ sorbitol both orally & as enemas, has been implicated in colonic necrosis. Treatment may be insufficient to rapidly improve severe hyperkalemia often associated w/ states or rapid tissue breakdown eg, burn or trauma; dialysis is recommended.
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