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In order to avoid the hypersensitive reaction described in the "adverse events", it is advisable to use slow infusion rate. For this purpose the drug is previously diluted with 5% Glucose or with physiological solution.
Loading dose: Bolus dose-NAC 150 mg/Kg in 60 minutes (at least 200 mL in the adult and 50 mL in the child in 5% glucose or physiological solution).
Subsequence doses: Treatment must be continued with 50 mg/Kg doses, at slow infusion rate, every 4 hours for a total of 72 hours of treatment.
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