Acute treatment & maintenance of schizophrenia & other psychoses when +ve &/or -ve symptoms are prominent. Moderate to severe manic episode. Prevention of recurrence in patient w/ bipolar disorder.
Dosage/Direction for Use
Schizophrenia & related disorder Starting dose: 10 mg daily. Manic episode Starting dose: 15 mg daily as a single dose in monotherapy or 10 mg daily in combination w/ lithium or valproate. Prevention of recurrence in bipolar disorder Starting dose: 10 mg daily.
Administration
May be taken with or without food.
Contraindications
Narrow-angle glaucoma.
Special Precautions
Hepatic impairment or patients on hepatotoxic drugs, history of seizures, prostatic hypertrophy, paralytic ileus, low leukocyte/neutrophil counts; history of drug-induced bone marrow depression due to concomitant illness, RT or chemotherapy; hypereosinophilic conditions w/ myeloproliferative disease. May impair ability to drive or operate machinery. Pregnancy & lactation.
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