Paraco Mechanism of Action

Pharmacology: Tab and syr: Analgesic-antipyretic.
As analgesic, works by increasing the pain threshold excitatory.
As antipyretic, thought to work directly on the heat regulating center in the hypothalamus.
Drops: The working mechanism of Paracetamol as an antipyretic agent is assumed to be based on the central effect equivalent to salicylic.
The antipyretic effect of Paracetamol can be described as follows: In the state of fever, the central heat regulator of the hypothalamus is estimated to undergo some trouble that the body temperature becomes elevated.
Paracetamol is believed to work out by making the central heat regulator back to normal again.
Paracetamol does not have a direct effect against blood vessels and cebacea gland, though this effect is central in characteristic, it does not perform a direct effect against the hypothalamus neurons.
Sweat formation comprises on outstanding effect after the administration of Paracetamol. However, it is not the result of its essential mechanism.
Paracetamol still reduces fever when the sweat formation is hindered by the administration of atropine.
The effect of fever reduction is supposed to take place by inhibiting the prostaglandin formation as its analgesic effect is similarly supposed to happen.
Prostaglandin E is a potent pyrogen which affect, when injected to the brain ventricle through hypothalamus anterior, cannot be inhibited by an antipyretic agent.
Pyrogen promotes the formation of Prostaglandin E, and the formation of this substance is still inhibited by Paracetamol.