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Pharmacology: Inhibition of wall synthesis sets. Cefixime has a high affinity for penicillin-binding protein (PBP) 1 (la, 1 b, 1c) and 3, on the side which affects several organism activities.
Microbiology: Antibacterial activity: Cefixime has a wide spectrum against gram-positive and gram-negative microorganisms. When compared with other cephalosporins, cefixime has potent activity against gram-positive organisms such as Streptococcus spp, Streptococcus pneumonias and gram negatives such as Branhamella catarrhalis, Eschericia coli, Proteus spp, Haemophilus influenzae. This substance acts as bactericidal. Cefixime is very stable against n-lactamase-producing organisms.
