Meptin Inhalation Solution Drug Interactions

Meptin Inhalation Solution should be administered with care when co-administered with the following drugs: Catecholamines (eg, Epinephrine and Isoproterenol): Signs, Symptoms and Treatment: The combined use of Meptin Inhalation Solution with catecholamines may cause arrhythmias or in some cases, cardiac arrest.
Mechanism or Risk Factors: Epinephrine, isoproterenol and other catecholamines potentiate adrenoreceptor-stimulating action of Meptin Inhalation Solution, possibly resulting in the induction of arrhythmias.
Xanthine Derivatives (eg, Theophylline, Aminophylline and Diprophylline): Signs, Symptoms and Treatment: The combined use Meptin Inhalation Solution with xanthine derivatives may aggravate hypokalemia and cardiovascular adverse reactions (eg, tachycardia, arrhythmias) due to β-adrenergic stimulations. If any of these abnormalities are observed, appropriate measures eg, dose reduction or treatment discontinuation should be taken.
Mechanism and Risk Factors: Xanthine derivatives potentiate adrenoreceptor-stimulationg action of Meptin Inhalation Solution, possibly resulting in a decreased serum potassium and aggravating cardiovascular adverse reactions. The mechanism responsible for inductions of hypokalemia is not known.
Corticosteroids (eg, Betamethasone, Prednisolone and Hydrocortisone sodium succinate), and Diuretics (eg, Furosemide): Signs, Symptoms and Treatment: The combined use of Meptin Inhalation Solution with corticosteroids and diuretics may cause a decreased serum potassium levels, resulting in arrhythmias. If any of these abnormalities are observed, appropriate measures eg, dose reduction or treatment discontinuation should be taken.
Mechanism and Risk Factors: Corticosteroids and diuretics augment the excretion of potassium from renal tubules, possibly resulting in an excessive decresae in serum potassium levels.