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When administered concomitantly with alcohol, Loratadine has no potentiating effect as measured by psychomotor performance studies.
Increases plasma concentrations of Loratadine have been reported after concomitant use with Erithromycin, Ketoconazole, & Cimetidine in controlled clinical studies, but without clinically significant effect including electro-cardiographic parameters.
Caution should be exercised if Loratadine is coadministered with hepatic metabolism inhibitor medicines.
Administration of antihistamines should be discontinued about ± 48 hours prior to skin testing procedures, since these medicines may prevent or diminish otherwise positive reactions to dermal reactivity indicators.
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