Short-term symptomatic treatment of acute OA exacerbation. Long-term symptomatic treatment of RA (chronic polyarthritis). Symptomatic treatment of ankylosing spondylitis.
Dosage/Direction for Use
OA 7.5 mg daily. May be increased to 15 mg daily if needed. RA 15 mg daily. May be reduced to 7.5 mg daily. Ankylosing spondylitis 15 mg daily. May be increased to 7.5 mg daily. Patient w/ increased risk of side effects Initially 7.5 mg daily. Dialysis patient w/ severe kidney failure Max dose: 7.5 mg daily.
Contraindications
Hypersensitivity. Patients w/ symptoms of asthma, nasal polyp, angioedema or urticaria after administration of ASA or other NSAIDs. Peri-op pain in CABG. Active gastric ulcer/perforation. Active inflammatory bowel disease. GI & cerebral blood vessel bleeding or other hemorrhage disorders. Uncontrolled acute heart failure. Severe hepatic insufficiency. Non-dialysis severe kidney insufficiency. Pregnancy & lactation. Childn & adolescent <15 yr.
Special Precautions
Patients w/ or at risk of CV disease; dehydration; CHF; liver cirrhosis; nephrotic syndrome & other kidney disorders. May cause hypovolemia in patients undergoing major surgery. History of GI bleeding. Monitor patients w/ symptoms of GI disease. Concomitant use w/ anticoagulants; diuretics, ACE inhibitor, AIIA. Women planning a pregnancy or undergoing infertility investigation. Elderly.
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