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Treatment should be discontinued in case of ataxia, vertigo, hallucinations mental confusion.
Metronidazole should be used with caution in patients with active or chronic severe peripheral and central nervous system diseases due to the risk of neurological aggravation. Disturbances of central nervous system has been reported in some cases but disappeared if therapy is discontinued or dose decreased.
Patients should be advised not to take alcohol during metronidazole therapy and for at least one day afterwards because of the possibility of a disulfiram like (Antabuse effect) reaction.
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