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Pharmacology: Sucralfate is a complex formed from sucrose octasulphate and polyaluminum hydroxide.
Its anti-ulcer activity is the result of ulcer-adherent protein-Sucralfate complex that covers the ulcer site and protects it against further attack of acid, pepsin and bile salts.
Sucralfate may promote the healing of peptic ulcers in 3 ways: 1. Forming a chemical complex that binds to the ulcer site to establish a protective barrier.
2. Directly inhibits the actions of acid, pepsin and bile.
3. Blocking the diffusion of gastric acid through the barrier of Sucralfate-albumin.
Sucralfate remains in the Gl tract for extended periods, prolonging the therapeutic actions of the drug.
Furthermore, Sucralfate is minimally absorbed from the GI tract which results in significant systemic side effects.
