Coveram Dosage/Direction for Use

1 tablet/day as a single dose, preferably to be taken in the morning and before a meal.
The fixed dose combination is not suitable for initial therapy. If a change of posology is required, the dose of Coveram could be modified or individual titration with free combination may be considered.
Patients with Renal Impairment and Elderly: (See Precautions and Pharmacokinetics under Actions.) Elimination of perindoprilat is decreased in the elderly and in patients with renal failure. Therefore, the usual medical follow-up will include frequent monitoring of creatinine and potassium.
Coveram can be administered in patients with creatinine clearance (Clcr) ≥60 mL/min and is not suitable for patients with Clcr <60 mL/min. In these patients, an individual dose titration with the noncomponents is recommended.
Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment.
Patients with Hepatic Impairment: (See Precautions and Pharmacokinetics under Actions.)
A dosage regimen for patients with hepatic impairment has not been established. Therefore, Coveram should be administered with caution.
Adolescents and Children: Coveram should not be used in adolescents and children as the efficacy and tolerability of perindopril and amlodipine, alone or in combination, have not been established in adolescents and children.