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Posology: The usual posology is one tablet once daily.
Patients should be stabilized with bisoprolol and perindopril at the same dose level for at least 4 weeks. The fixed dose combination is not suitable for initial therapy.
If a change of posology is required, titration should be done with the individual components.
Special population: Renal impairment: Cosyrel is not suitable for patients with renal impairment.
Individual dose titration with the monocomponent is recommended.
Hepatic impairment: No dosage adjustment is necessary in patients with hepatic impairment.
Elderly: Cosyrel should be administered according to the renal function.
Paediatric population: The safety and efficacy of Cosyrel in children and adolescents have not been established. No data are available. Therefore, use in children and adolescents is not recommended.
Method of administration: Cosyrel tablet should be taken as a single dose once daily in the morning before a meal.
