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Pharmacology: Cefixime has a broad spectrum activity against Gram-positive and Gram-negative microorganisms. In particular, in comparison with other oral cephalosporins, it has potent activity against such Gram-positive organisms as Streptococcus sp, Streptococcus pneumoniae, and such Gram-negatives as Branhamella catarrhalis, Escherichia coli, Proteus sp, Haemophilus influenzae, Neisseria gonorrhoeae. Its mode of action is bactericidal. Cefixime is extremely stable to β-lactamase producing organisms.
Cefixime mode of action is inhibition of cell wall synthesis. It has high affinity for penicillin-binding protein (PBP) 1 (1a, 1b, and 1c) and 3, with the site of activity varying according to organism.
