Blopress Dosage/Direction for Use

Dosage in Hypertension: The recommended dose of Blopress is 4 mg once daily. The dose should be titrated according to response up to 16 mg once daily. The maximum antihypertensive effect is attained within 4 weeks after initiation of treatment.
Use in the Elderly: No dosage adjustment is necessary for patients up to 75 year. In patients >75 years, an initial dose of 2 mg once daily is recommended. The dose may be titrated up according to response.
Use in patients with impaired renal function: No dosage adjustment is necessary in patients with mild renal impairment. In patients with moderate to severe renal impairment, an initial dose 2 mg once daily is recommended. The dose may be titrated up according to response.
Use in the patient with impaired hepatic function: An initial dose of 2 mg once daily is recommended in patients with mild to moderate hepatic impairment. The dose may be titrated up according to response. There is no experience in patients with severe hepatic impairment.
Concomitant therapy: Blopress may be administered with other antihypertensive agents.
Use in children: The safety and efficacy of Blopress have not been established in children.
Dosage in Heart Failure: The usual recommended initial dose of Blopress is 4 mg once daily. Up-titration to the target dose of 32 mg once daily or the highest tolerated dose is done by doubling the dose at intervals of at least 2 weeks.
Special patient populations: No initial dose adjustment is necessary for elderly patients or in patients with intravascular volume depletion, renal impairment or mild to moderate hepatic impairment.
Concomitant therapy: Blopress can be administered with other heart failure treatment, including ACE-inhibitors, beta-blockers, diuretics and digitalis or a combination of these medicinal products.
The combination of an ACE inhibitor, a potassium - sparing diuretic (e.g. spironolactone) and Blopress is not recommended and should be considered only after careful evaluation of the potential benefits and risks.
Administration: Blopress should be taken once daily with or without food.
Use in children & adolescents: The safety and efficacy of Blopress have not been established in children and adolescents (under 18 years).