Sign Out
Symptoms: Limited data are available for overdosage in humans. Symptoms associated with overdosage of ACE inhibitors may include hypotension, circulatory shock, electrolyte disturbances, renal failure, hyperventilation, tachycardia, palpitations, bradycardia, dizziness, anxiety and cough.
Treatment: The recommended treatment of overdosage is IV infusion of 0.9% sodium chloride 9 mg/mL solution. If hypotension occurs, the patient should be placed in the shock position. If available, treatment with angiotensin II infusion and/or IV catecholamines may also be considered. Perindopril may be removed from the general circulation by haemodialysis (see Precautions). Pacemaker therapy is indicated for therapy-resistant bradycardia. Vital signs, serum electrolytes and creatinine concentrations should be monitored continuously.
