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Due to the lack of sufficient therapeutic experience, Bioprexum Plus should not be used in dialysis patients and patients with untreated decompensated heart failure.
Perindopril: Hypersensitivity to perindopril or any other ACE inhibitor. History of angioedema (Quincke's edema) associated with previous ACE inhibitor therapy. Hereditary/idiopathic angioedema. 2nd and 3rd trimesters of pregnancy (see Use in pregnancy & lactation under Precautions).
Indapamide: Hypersensitivity to indapamide or to any other sulphonamides. Severe renal impairment (CrCl <30 mL/min). Hepatic encephalopathy. Severe hepatic impairment. Hypokalemia. As a general rule, indapamide is inadvisable in combination with non-antiarrhythmic agents causing Torsades de pointes (see Interactions). Lactation (see Use in pregnancy & lactation under Precautions).
