Zyrtec-D Adverse Reactions

Drug safety information from clinical tests: In controlled clinical trials, adverse reactions reported in more than 1% of the patients receiving the combination cetirizine/psuedoephedrine, were not different from those reported for cetirizine or pseudoephedrine alone.
Post Marketing Experience: Undesirable effects encountered with cetirizine are mainly related to CNS depressant or paradoxical CNS stimulation effects, to anticholinergic-like activity or hypersensitivity reaction (including anaphylactic shock), while the undesirable effects of pseudoephedrine are more likely related to CNS stimulation, and cardiovascular disorders. Isolated cases of stroke and ischemic colitis associated with pseudoephedrine use have been identified in literature.
The following undesirable effects have been reported. They are displayed according to MedDRA primary System Organ Classes and by estimated frequency. Frequencies are defined as follows: Very common (≥1/10); common (≥1/100, <1/10); uncommon (≥1/1000, <1/100); rare (≥1/10000, <1/1000); very rare (<1/10000), not known (cannot be estimated from the available data): See Table.

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